Vitamin dan Obat Ternak Sapi

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DOXYVETo - 50S

Price

Rp 1,260,000

DOXYVETo - 50S

Poultry:
Chronic Respiratory Disease (M. gallisepticum), Ornithosis (Chlamydia psittaci), Infectious synovitis (M. synoviae), Fowl cholera (P. Multocida).



DOSAGE ET ADMINISTRATION
For oral administration via drinking water, milk or feed.

Calves, lambs:
10 mg doxycycline per kg body weight per day in milk or drinking water.
(= 1 g of DOXYVETo- 50 S per 50 kg body weight)`

Pigs:
10 mg doxycycline per kg body weight per day in feed or drinking water. (=
500-600 g DOXYVETo-50 S per ton of feed or 200-250 g per 1000 litre).

Poultry:
20 mg of doxycycline per kg body weight per day in drinking water (= 300 g of DOXYVETo-50 S per 1000 litre of drinking water or 600 g DOXYVETo - 50 S per 1000 kg of feed).

Medicated water (< 25°C) should be refreshed every 12 hours. Treatment should be continued during 3 to 5 consecutive days.

PHARMACODYNAMIC PROPERTIES
Doxycycline is a broad-spectrum antibiotic belonging to the group of tetracyclines. It has a bacteriostatic action against both Gram-positive and Gram-negative bacteria, spirochaetes, leptospirae, actinomyces, rickettsiae, mycoplasms and bedsoniae. It acts by binding to the bacterial ribosome which leads to an inhibition of the protein synthesis. Low MIC-values are reported for some pathogens which play an important role in diseases of the respiratory tract. Apart from some exceptions, it can be stated that the antimicrobial activity of doxycycline is, in-vitro, superior to that of the older tetracyclines.

Strains of Pseudomonas aeruginosa, Proteus, Serratia, Klebsiella, and Corynebacterium spp. frequently are resistant, as are many pathogenic Escherichia coli isolates. In recent years, higher prevalence of resistance is observed in Pasteurella spp. isolated from diseased calves. There is a general cross-resistance among tetracyclines, although some resistant strains remain sensitive towards doxycycline.

PHARMACOKINETIC PROPERTIES
Following oral administration of DOXYVETo-50 S, doxycycline is resorbed slowly, but almost completely. When a daily dose of 10 mg/kg bw. is administered, steady-state plasma concentrations of at least 2 μg/ml (in calves) and 0.5 μg/ml (in pigs) are maintained. Doxycycline is highly bound to serum proteins (more than 90% in calves and pigs) and is distributed very well. High concentrations of doxycycline, approximately twice the corresponding serum levels, are obtained in the lungs. The elimination half-life is long in calves (final elimination half-life is in the range of 27-46 hours), but is shorter in pigs (6 hours following oral administration in feed). Although elimination via the kidneys plays a role in the total elimination of doxycycline, the main route of excretion for orally administered doxycycline is via the gastro-intestinal tract (liver and bilary tract). Therefore no dose-adjustment is necessary in animals with an impaired renal function, as no accumulation will occur.

CONTRA-INDICATIONS
- Hypersensitivity to tetracyclines.
- Do not administer to ruminating animals.

SIDE-EFFECTS
Some minor gastro-intestinal disturbances may occur. White veal calves seem particularly sensitive to doxycycline: some cases of sudden death have been reported with therapeutic doses of doxycycline.

SPECIAL PRECAUTIONS FOR USE
No special precautions for use are necessary.
Direct skin contact and inhalation of the powder should be avoided.

USE DURING GESTATION AND LACTATION
The use during gestation and lactation should be avoided or restricted to severe infections because doxycycline is deposited in the growing
bone tissue.

INTERACTIONS
Antagonism between tetracyclines and bactericidal drugs such as penicillins, cephalosporins and aminoglycosides.

OVERDOSING
Overdosage can cause gastro-intestinal disturbances. The therapy should be stopped in severe cases.